Misturah Yetunde Adana

@unilorin.edu.ng

Associate Professor, Faculty of Basic Medical Sciences
Deputy Director, Others
university of Ilorin

Misturah Yetunde Adana


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https://researchid.co/misturahadana
Dr. Misturah Adana is a passionate physician-scientist whose career beautifully bridges patient care, cutting-edge research, and transformative mentorship. Beginning in clinical practice, her deep curiosity about health and disease led her into the world of laboratory science, where she now explores how natural products especially phytochemicals can unlock affordable, life-changing therapies for vulnerable communities. As Deputy Director at the Institute of Medical Research and Training (IMRAT), University of Ilorin, she teaches, mentors, and leads groundbreaking research. Driven by a vision to merge traditional wisdom with modern innovation, Dr. Adana is building a dynamic, inclusive research culture that inspires the next generation of changemakers.

EDUCATION

1. Doctor of Philosophy ( Anatomy 2019
2. Master of Public Health (M.P.H.) 2016
3. Master of Science (M.Sc. Anatomy) 2015
4. Bachelor of Medicine, Bachelor of Surgery (M.B; B.S) 2008

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Reproductive Medicine, Public Health, Environmental and Occupational Health, Neuroscience
10

Scopus Publications

Scopus Publications

  • Craniofacial genetics as a differential identification tool: analysis of a subset of Yoruba-speaking population in Nigeria
    Suwebat Bidemi Kareem, Olugbenga Akinola, Oluyinka Ajibola Iyiola, Misturah Yetunde Adana, Ade Stephen Alabi, et al.
    Egyptian Journal of Medical Human Genetics, 2025
    Background Population-dependent genetics and normal-range variations in facial morphology have been reported across several populations, but there is paucity of literature on the African population. The study was designed to evaluate the potentials of craniofacial genetics as a differential identification tool amongst the Yoruba-Ethnic nationality in Nigeria. An anthropometric study of two thousand one hundred and nine (2109) randomly selected individuals (age 15–29 years) was conducted. The personal information of participants was obtained using semi-structured, self-administered questionnaires, while craniofacial parameters were measured from facial photographs with Digimizer software. DNA was isolated from buccal swabs samples obtained from three hundred participants (300) after careful stratifications to match the chosen ethic group. Segments of two craniofacial-associated genetic markers (PAX3 and BMP4 genes) were amplified from participant’s DNA samples using polymerase chain reaction technique. The amplified gene segments were purified, sequenced, and aligned with the reference sequences from the NCBI database. Results A total of 45 samples were observed with synonymous and non-synonymous changes across the 2 genes. These genetic changes were not significantly associated with craniofacial differences in the study population. However, two participants, one each for PAX3 and BMP4, displayed higher polymorphisms that were associated with values of different craniofacial linear parmeters {Nasal width (al–al), Nasal height (n-sn), Morphological facial height (n-gn), Bizygomatic distance (zy–zy), Interendocanthal width (en–en), Ear width (t-pa), Ear height (sa-sba), Mandible height (sto-gn), Mouth width (ch–ch), Vermillion height (ls-sto), Eye fissure width@ R(en-ex)}, different from the general population not statistically significant. Conclusion The slight differences in craniofacial parameter measurements in two individuals, with novel polymorphisms (SNPs) loci in PAX3 and BMP4 provides insights to baseline data for validation of cranio-genetic markers that may be useful in the population under study.
  • Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186: Inhibition of neuroinflammation and neuronal damage by the selective non-steroidal ERβ agonist AC-186: F. O. Katola et al.
    Folashade O. Katola, Misturah Y. Adana, Olumayokun A. Olajide
    Inflammation Research, 2024
    Background: AC-186 (4-[4-4-Difluoro-1-(2-fluorophenyl) cyclohexyl] phenol) is a neuroprotective non-steroidal selective oestrogen receptor modulator. This study investigated whether inhibition of neuroinflammation contributed to neuroprotective activity of this compound. Methods: BV-2 microglia were treated with AC-186 (0.65–5 μM) prior to stimulation with LPS (100 ng/mL). Levels of pro-inflammatory mediators and proteins were then evaluated. Results: Treatment of LPS-activated BV-2 microglia with AC-186 resulted in significant (p < 0.05) reduction in TNFα, IL-6, NO, PGE2, iNOS and COX-2. Further investigations showed that AC-186 decreased LPS-induced elevated levels of phospho-p65, phospho-IκBα and acetyl-p65 proteins, while blocking DNA binding and luciferase activity of NF-κB. AC-186 induced significant (p < 0.05) increase in protein expression of ERβ, while enhancing ERE luciferase activity in BV-2 cells. Effects of the compound on oestrogen signalling in the microglia was confirmed in knockdown experiments which revealed a loss of anti-inflammatory activity following transfection with ERβ siRNA. In vitro neuroprotective activity of AC-186 was demonstrated by inhibition of activated microglia-mediated damage to HT-22 neurons. Conclusions: This study established that AC-186 produces NF-κB-mediated anti-inflammatory activity, which is proposed as a contributory mechanism involved in its neuroprotective actions. It is suggested that the anti-inflammatory activity of this compound is linked to its agonist effect on ERβ.
  • Screening for pulmonary hypertension in pregnant women with sickle cell disease in sub-Saharan Africa
    Alim Swarray-Deen, Misturah Y. Adana, Micheal A. Alao, Victoria A.A. Agyen-Frimpong, Adekunle Fakunle, et al.
    Ajog Global Reports, 2024
  • Phoenix dactylifera and Polyphenols Ameliorated Monosodium Glutamate toxicity in the Dentate Gyrus of Wistar Rats
    Ruqayyah Ibiyeye, Fatimo Sulaimon, Aminu Imam, Misturah Adana, Akeem Okesina, et al.
    Nigerian Journal of Physiological Sciences, 2023
    Monosodium glutamate (MSG) has been known to cause neurodegeneration, due to its ability to trigger excitotoxicity, and the hippocampus is one of the most affected regions. Therefore, Phoenix dactylifera (P. dactylifera) and polyphenols was employed in this study to mitigate on the deleterious effect of monosodium glutamate on the dentate gyrus of Wistar rats. Forty-eight male Wistar rats weighing between 120-150g was used for the study. The Wistar rats were grouped into eight, (n=6). Groups 1-8 received 1.6mL/kg normal saline, 4000mg\\kg monosodium glutamate for 7-days, 4000mg\\kg monosodium glutamate for 7-days and 100mg\\kg caffeic-acid for 14-days concurrently, 4000mg\\kg monosodium glutamate for 7-days and 100mg\\kg Phoenix dactylifera for 14-days concurrently, 4000mg\\kg monosodium glutamate for 7-days and 100mg\\kg luteolin for 14-days concurrently, 100mg\\kg. caffeic-acid for 14-days followed by 4000mg\\kg monosodium glutamate for 7-days, 100mg\\kg Phoenix dactylifera for 14-days followed by 4000mg\\kg monosodium glutamate for 7-days and 100mg\\kg luteolin for 14-days followed by 4000mg\\kg monosodium glutamate for 7-days respectively. After the treatments, the rats underwent behavioural tests, and subsequently, the brain tissues were processed for histological and biochemical analyses. The activities of P. dactylifera and polyphenols ameliorated the deleterious effect of monosodium glutamate, through increased spontaneous alternation of the experimental animals, dominant matured granule cells of the dentate gyrus and modulated the activities of superoxide dismutase, glutathione peroxidase and malondialdehyde in the of male Wistar rats. Therefore, this study revealed that P. dactylifera and polyphenols ameliorated monosodium glutamate toxicity in the dentate gyrus of Wistar rats.
  • Oral thymoquinone modulates cyclophosphamide-induced testicular toxicity in adolescent Wistar rats
    Misturah Y. Adana, Aminu Imam, Ahmed A. Bello, Olawale E. Sunmonu, Ezekiel P. Alege, et al.
    Andrologia, 2022
    Cyclophosphamide (CYP) is an effective anti‐cancer drug that is widely accepted, but it is not devoid of unintended toxic effects. Gonadal toxicity is reported as one of the side effects of its long‐time use. This study examined the effects of thymoquinone (TQ) on the biological integrities of the testes after cyclophosphamide exposure. Thirty adolescent male Wistar rats (100–110 g) were divided into six groups (n = 5), receiving normal saline (NS), 20 mg/kg of CYP (CYP), 5 mg/kg of TQ (TQ5), 10 mg/kg of TQ (TQ10), 20 mg/kg of CYP and 5 mg/kg of TQ (CTQ5), and 20 mg/kg of CYP and 10 mg/kg of TQ (CTQ10) respectively. On the 22nd day, blood, semen and testicular samples were collected for the assay of serum reproductive hormones (follicle‐stimulating (FSH) and luteinizing (LH) hormones), semen analysis and testicular histology and proliferating cell nuclear antigen (PCNA) expression. The results revealed that CYP exposure affected functional and structural integrities of the testes, by depleting sperm count and motility, testosterone, LH, spermatogenic and mature sperm cell population, Leydig cells and PCNA immunoreactive proliferating cells. TQ interventions were able to reverse all cytotoxic CYP impacts, but with differential activities on the hormonal concentrations, specifically LH and FSH. Cumulatively, thymoquinone may be a potent agent against cyclophosphamide effects on the physiological, regeneration and histological integrities of the testes, as observed in this study.
  • Body donation trends at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal over a three-decade period (1988–2017): Implications for medical education
    Misturah Yetunde Adana, Edwin Coleridge Stephen Naidu, Onyemaechi Okpara Azu
    Transactions of the Royal Society of South Africa, 2019
    Dissection and prosection remain the gold standards for the teaching of anatomy to pre-clinical medical students around the world. This has made the practice of whole body donation the cornerstone of medical programmes. This study aims to determine the trends in body donation among South Africans and predict the best possible and realistic approach for the teaching of anatomy in the near future. Data from 696 cadavers donated during a three-decade period (1988–2017) were obtained from the files of the Discipline of Clinical Anatomy, University of KwaZulu-Natal South Africa. Data were analysed as percentages, mean ± standard deviation using Statistical package for social sciences version 24. Most bodies were donated in the first decade of this study (1988–1997). Family bequests through funeral services accounted for the majority of donations. Bodies were predominantly in the seventh decade of life (18.8%) and a larger proportion were males (61.6%). Bequests were found to be more among the whites (57.5%) than all the other races. The causes of death in donors were from a wide range of conditions. The study revealed that the trend in the practice of body donation in South Africa has been erratic, which makes it difficult to predict the number of bodies available for medical education. Alternative approaches to anatomy education such as plastination techniques and computational models need to be sought to ensure sound and uninterrupted medical programmes in South African schools.
  • Testicular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin
    Misturah Yetunde Adana, Edidiong Nnamso Akang, Edwin Coleridge Stephen Naidu, Peter Imo Aniekan, Koffi Kouame, et al.
    Andrologia, 2018
    Human immunodeficiency virus‐infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into—A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinising hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it promises to be a beneficial adjuvant for mitigating HAART testicular and reproductive perturbations.
  • Effect of long-term administration of cinnamomum cassia silver nanoparticles on organs (Kidneys and liver) of sprague-dawley rats
    Koffi KOUAME, Aniekan Imo PETER, Edidiong Nnamso AKANG, Misturah ADANA, Roshila MOODLEY, et al.
    Turkish Journal of Biology, 2018
    This study investigated the toxic effects of silver on the kidneys and livers of Sprague-Dawley rats after administering multiple doses of silver nanoparticles synthesized using extracts of Cinnamomum cassia (CcAgNPs). Twenty-four Sprague-Dawley rats (250 ± 20 g) were randomly assigned to four groups (A-D) of six animals per group and treated for 8 weeks. Group A was administered 200 mg/kg of Cinnamon Cassia extract (Cc), group B 5 mg/kg of CcAgNPs, group C 10 mg/kg of CcAgNPs, and group D normal saline. Body weight was measured weekly and fasting blood glucose was measured fortnightly. At the end of the experiment, animals were euthanized and organs (livers and kidneys) were fixed in neutral buffered formalin and processed for light microscopy (H&E). Body weight differences were significantly higher (P < 0.05) in the low-dose Cc group and the kidney to body weight ratio was not significant. Renal function analysis of proteins and ketones showed a significant increase in CcAgNP-treated rats (P < 0.05). Kidney and liver histology showed distortions in hepatocytes and sinusoidal linings with infiltrations especially in the higher dose groups. Kidney histology mirrored degenerative changes in glomerular and Bowman's capsules with bfirillary mesangial interstitium. CcAgNPs impairs renal and hepatic morphology and function after a long period of administration.
  • Naringenin attenuates highly active antiretroviral therapy-induced sperm DNA fragmentations and testicular toxicity in Sprague-Dawley rats
    M. Y. Adana, E. N. Akang, A. I. Peter, A. I. Jegede, E. C. S. Naidu, et al.
    Andrology, 2018
    SummaryHighly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living withHIVandAIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study is to determine the adjuvant potential of Naringenin on highly active antiretroviral therapy‐induced perturbations in fertility of male Sprague‐Dawley rats. Thirty adult male Sprague‐Dawley rats were divided into six groups viz – Control; H: 30 mg/kg of highly active antiretroviral therapy (EFV, 600 mg +FTC, 200 mg +TDF, 300 mg); N40: Naringenin, 40 mg/kg; N80: Naringenin, 80 mg/kg;HN40: highly active antiretroviral therapy + Naringenin, 40 mg/kg;HN80: highly active antiretroviral therapy + Naringenin, 80 mg/kg. The rats were euthanized after 4 weeks. Results showed that there was a significant decrease in sperm count (p &lt; 0.001), spermatozoa with normal morphology (p &lt; 0.001) and progressive sperm motility (p &lt; 0.05) of H compared to the control and theHNgroups. Likewise, fragmentations increased (p &lt; 0.05) in tail lengths of spermDNAin H compared to control.HN40 andHN80 decreased tail lengths compared to H (p &lt; 0.001). There was also a decrease in %tailDNAand tail moment inHN40 (p &lt; 0.001) compared to H. Luteinizing hormone significantly increased (p &lt; 0.05) inHN40,HN80, and N40 (p &lt; 0.001) but decreased in H (p &lt; 0.05) compared to control. The diameter of the seminiferous tubules also decreased (p &lt; 0.05) in H compared to control, N80, andHN40. Likewise, the area of the seminiferous tubules in group H decreased (p &lt; 0.05) compared to N80 andHN80. The seminiferous tubules epithelium increased (p &lt; 0.05) in N40 andHN40 compared to H. This study establishes that highly active antiretroviral therapy has deleterious effects on the testicular microanatomy, sperm parameters, and spermDNAof Sprague‐Dawley rats, which may impair fertility but Naringenin is a potential complimentary adjuvant.
  • Dichlorvos induced oxidative and neuronal responses in rats: Mitigative efficacy of Nigella sativa (Black Cumin)
    Nigerian Journal of Physiological Sciences, 2018